GOTCHA

Novel gene-independent and signature-based metagenomic taxonomic profiling

Genomic Origin Through Taxonomic CHAllenge

GOTTCHA (Genomic Origin Through Taxonomic CHAllenge) is an application of a novel, gene-independent and signature-based metagenomic taxonomic profiling method with significantly smaller false discovery rates (FDR) that is also laptop deployable. Our algorithm was tested and validated on twenty synthetic and mock datasets ranging in community composition and complexity, was applied successfully to data generated from spiked environmental and clinical samples, and robustly demonstrates superior performance compared with other available tools.

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For more information see our publication:

Accurate read-based metagenome characterization using a hierarchical suite of unique signatures

Freitas TA, Li P, Scholz MB, Chain PSG